Genomic and metagenomic challenges and opportunities for bioleaching: a mini-review.
نویسندگان
چکیده
High-throughput genomic technologies are accelerating progress in understanding the diversity of microbial life in many environments. Here we highlight advances in genomics and metagenomics of microorganisms from bioleaching heaps and related acidic mining environments. Bioleaching heaps used for copper recovery provide significant opportunities to study the processes and mechanisms underlying microbial successions and the influence of community composition on ecosystem functioning. Obtaining quantitative and process-level knowledge of these dynamics is pivotal for understanding how microorganisms contribute to the solubilization of copper for industrial recovery. Advances in DNA sequencing technology provide unprecedented opportunities to obtain information about the genomes of bioleaching microorganisms, allowing predictive models of metabolic potential and ecosystem-level interactions to be constructed. These approaches are enabling predictive phenotyping of organisms many of which are recalcitrant to genetic approaches or are unculturable. This mini-review describes current bioleaching genomic and metagenomic projects and addresses the use of genome information to: (i) build metabolic models; (ii) predict microbial interactions; (iii) estimate genetic diversity; and (iv) study microbial evolution. Key challenges and perspectives of bioleaching genomics/metagenomics are addressed.
منابع مشابه
A Systematic Review Opportunities and Challenges of Tele-cardiology in Health Care Systems
Aim: Telecardiology provides a useful diagnostic tool for accurate and rapid diagnosis of patients with cardiac disorders to specialist and general practitioners. In this study, a systematic review was conducted to identify effective components and approaches in Telecardiology, such as the opportunities and challenges of applying this system in different domains. Information sources or data: T...
متن کاملPutative bacterial interactions from metagenomic knowledge with an integrative systems ecology approach
Following the trend of studies that investigate microbial ecosystems using different metagenomic techniques, we propose a new integrative systems ecology approach that aims to decipher functional roles within a consortium through the integration of genomic and metabolic knowledge at genome scale. For the sake of application, using public genomes of five bacterial strains involved in copper biol...
متن کاملReview of Challenges and Opportunities Health Information Technology-based Art Therapy in Education and Treatment
متن کامل
Challenges and opportunities in understanding microbial communities with metagenome assembly (accompanied by IPython Notebook tutorial)
Metagenomic investigations hold great promise for informing the genetics, physiology, and ecology of environmental microorganisms. Current challenges for metagenomic analysis are related to our ability to connect the dots between sequencing reads, their population of origin, and their encoding functions. Assembly-based methods reduce dataset size by extending overlapping reads into larger conti...
متن کاملBenefits and Risks of Aquaculture Foods in Primary Health Care: A Mini-Review
Primary Health Care (PHC) is expected to serve as a basis for the countrychr('39')s health sector, of which it is the primary responsibility and priority, as well as the communitychr('39')s overall collective and economic prosperity. Promotion of food supply and proper nutrition are among eight elements of PHC. Protein deficiency is one of the most important health concerns in some parts of the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Research in microbiology
دوره 167 7 شماره
صفحات -
تاریخ انتشار 2016